Trypanosoma Genome Database

Select a Species

Choose a Trypanosoma species below to explore its genome assemblies, annotations, sequencing statistics, and comparative analyses.

8 GENOMES AVAILABLE

Trypanosoma cruzi

Kinetoplastea • Trypanosomatidae • Stercoraria

Causative agent of Chagas disease. The pangenome resource includes complete assemblies across multiple clades (A–D) and hybrid strains, with T2T-level resolution and full chromosomal annotation.

Pangenome T2T assembly

Explore T. cruzi

1 GENOME AVAILABLE

Trypanosoma evansi

Kinetoplastea • Trypanosomatidae • Salivaria

Causative agent of Surra, a wasting disease affecting livestock across Asia, Africa, and Latin America. Transmitted mechanically by biting flies; notable for the absence of maxicircle kinetoplast DNA in some strains.

Genome Annotation Comparative

Explore T. evansi

coming soon

Trypanosoma vivax

Kinetoplastea • Trypanosomatidae • Salivaria

Major pathogen of cattle in sub-Saharan Africa and South America. Transmitted by tsetse flies and mechanical vectors; responsible for significant economic losses in tropical livestock production systems.

Genome Annotation Comparative

Explore T. vivax

Publications

Greif, G., Chiribao, M., Diaz-Viraque, F. et al.
The complete genome of Trypanosoma cruzi reveals 32 chromosomes and three genomic compartments.
BMC Genomics (2026). https://doi.org/10.1186/s12864-025-12482-0

Díaz-Viraqué F, Greif G, Berná L, Robello C.
Nanopore Long Read DNA Sequencing of Protozoan Parasites: Hybrid Genome Assembly of Trypanosoma cruzi.
Methods Mol. Biol. (2021). https://doi.org/10.1007/978-1-0716-1681-9_1

Díaz-Viraqué F, Chiribao ML, Libisch MG, Robello C.
Genome-wide chromatin interaction map for Trypanosoma cruzi
Nat. Microbiol. (2023). https://doi.org/10.1038/s41564-023-01483-y

Díaz-Viraqué F, Pita S, Greif G, de Souza RCM, Iraola G, Robello C.
Nanopore Sequencing Significantly Improves Genome Assembly of the Protozoan Parasite Trypanosoma cruzi.
Genome Biol. Evol. (2019). https://doi.org/10.1093/gbe/evz129

Díaz-Viraqué F, Pita S, Greif G, de Souza RCM, Iraola G, Robello C.
Transcriptome Studies in Trypanosoma cruzi Using RNA-seq.
Methods Mol. Biol. (2019). https://doi.org/10.1007/978-1-4939-9148-8_3

Berná L, Rodriguez M, Chiribao ML, Parodi-Talice A, Pita S, Rijo G, Alvarez-Valin F, Robello C.
Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi.
Microb. Genom. (2018). https://doi.org/10.1099/mgen.0.000177

Simón, MX.; Robello, C.; Greif, G.
Genome sequence of a Trypanosoma evansi isolate from a dog in Uruguay.
Vet Parasitol Reg Stud Reports (2026). https://doi.org/10.1128/mra.00568-26

Greif, G.; Faral-Tello, P.; Scardoelli Vianna, C.; Hernandez, A.; Basmadjian, Y.; Robello, C.
The first case report of trypanosomiasis caused by Trypanosoma evansi in Uruguay.
MRA (2018). https://doi.org/10.1016/j.vprsr.2017.11.002

Greif G, Rodriguez M, Bontempi I, Robello C, Alvarez-Valin F.
Different kinetoplast degradation patterns in American Trypanosoma vivax strains: Multiple independent origins or fast evolution?
Genomics (2021). https://doi.org/10.1016/j.ygeno.2020.12.037

Greif G, Rodriguez M, Reyna-Bello A, Robello C, Alvarez-Valin F.
Kinetoplast adaptations in American strains from Trypanosoma vivax.
Mutat. Res. (2015). https://doi.org/10.1016/j.mrfmmm.2015.01.008

Greif G, Ponce de Leon M, Lamolle G, Rodriguez M, Piñeyro D, Tavares-Marques LM, Reyna-Bello A, Robello C, Alvarez-Valin F.
Transcriptome analysis of the bloodstream stage from the parasite Trypanosoma vivax.
BMC Genomics (2013). https://doi.org/10.1186/1471-2164-14-149

About This Resource

This database provides curated genomic data for Trypanosoma species of medical and veterinary importance. The T. cruzi pangenome currently includes 8 fully assembled strains spanning Clades A, B and hybrid lineages (BC), with telomere-to-telomere (T2T) resolution for selected strains (Dm28c, Greif et al. 2026). Resources for T. evansi and T. vivax are under active development.